Bayville Chemical Supply Company Inc 70-G East Jefryn Boulevard Deer Park, New York, 11729 USA Telephone: 631-586-4309 Fax: 631-254-5591 E-Mail: info@bayvillechemical.net
Bayville Chemical Supply Company Inc70-G East Jefryn BoulevardDeer Park, New York, 11729  USA           Telephone: 631-586-4309      Fax: 631-254-5591      E-Mail: info@bayvillechemical.net 

Tri-Calcium Phosphate

Penta calcium hydroxide tris (orthophosphate)

USP/NF  Pharmaceutical Grade

Direct Compression

Application:        

Calcium Phosphate Excipients for Tablet and Capsule Products

Calcium phosphates have been used in the pharmaceutical technology for many years. They have many physical and chemical properties that make them ideal candidates for the production of solid oral dosage forms. They are mainly used as fillers in order to bulk up formulations however, the function of calcium phosphates goes far beyond mere filler and the adequate utilization of their full functionality can support achieving the intended formulation goals.  Calcium phosphates are inorganic substances of mineral origin and therefore are characterized by exceptional chemical stability. For the same reason, they are compatible with most of known drug substances. The few exceptions include indomethacin and tetracycline antibiotics which form with the calcium ions hardly absorbable complexes. Tribasic calcium phosphate (USP) shows incompatibility with the tocopheryl acetate which is related to the large number of hydroxyl groups on the surface of the substance.

Calcium phosphate based excipients possess many functional properties making them ideal candidates for direct compression process. Due to their favorable particle size and shape calcium phosphates exhibit excellent flowability. Furthermore, they enable to govern the flow pattern of poorly flowable powders, which allows for relatively easy preparation of tableting mixtures without the granulation. Very high density of calcium salts of ortho-phosphoric acid allows either using of larger amounts of excipients without increasing the size of the dosage form or decreasing it when the same quantity of excipient is used.

 Typical Properties:

Formula

Ca5(PO4)3OH

CAS Number

[12167-74-7]

Molecular Weight

502.3 g/mol

Assay (Purity)

99.4%

Assay (Calcium)

38.6%

Assay after ignition

102.5%

CaO

53.9% (Ca = 38.6%)

P2O5

40.5% (P = 17.7%)

P2O5 on anhydrous basis

41.4%

Loss on Ignition

3.3 (800oC)

pH

7.0 (10% suspension)

Aluminum

< 200 ppm

Iron

< 400 ppm

Cadmium

< 0.5 ppm

Lead

< 0.5 ppm

Arsenic

< 1.0 ppm

Mercury

< 1.0 ppm

Cobalt

< 5.0 ppm

Vanadium

< 3.0 ppm

Nickel

< 6.0 ppm

Barium Test

Passes Test

Chloride

0.01%

Fluoride

19 ppm

Sulfate

< 0.1 ppm

Nitrate Test

Passes Test

Carbonate Test

Passes Test

Identification Test

Passes Test

H2O Soluble substances

0.2%

HCl insoluble Substances

< 0.1%

Dibasic Salt and CaO

14 ml

Retained on 0.045 mm (US 325 wet sieve)

3.0%

Median Particle Size (D50)

5 microns

Bulk Density

250 gm/l

Quality and Environmental Standards

 

Product is best to our knowledge is free of:

 

 

Allergens

 

BSE/TSE (no material of animal origin being used)

 

GMO (Genetically Modified Organisms)

 

Residual Solvents

This product conforms to the following:

 

 

Halal and Kosher standards

 

Vegetarian and Vegan (mineral origin)

 

US-FDA GRAS-status: §182.1217

         

Packaging:               25 kg Bags

Storage: Store at room temperature in protected area in well closed containers.

Where to Find Us:

Bayville Chemical
70 East Jefryn Boulevard
Suite G
Deer Park, NY 11729

e-mail: info@bayvillechemical.net
Phone: 631 586-4309

What's New

New larger location

As of August 2014, we have moved to this new, larger, modern facility to better service your needs.

 



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