Hydroxyurea USP
CAS# 127-07-1
MF# CH4N2O2
MW# 76.05
Batch # 20081203
Code # Sample
Date of Mfg: 12/2008
Date of Exp: 12/2012
Synonyms: Hydrocarbamide
TEST SPECIFICATION RESULT
Appearance Crystalline Powder Complies
Identification (IR) As per Standard Complies
Melting Point 138˚C-145˚C 142˚ C
Loss on Drying < 0.5% 0.12%
Solubility Soluble in water and Hot alcohol Complies
Urea < 0.05% 0.02%
Sulphate Ash < 0.2% 0.04%
Heavy Metal < 20ppm Complies
Assay (HPLC) > 97% 99.35%
Microbiological Test:
Total Plate Counts < 1000 cfu/g Complies
Yeast and Mold < 100 cfu/g Complies
Enterobacteria < 100 cfu/g Complies
Salmonella Negative Complies
E.Coli Negative Complies
Pseudomonas aeruginosa Negative Complies
Hydroxyurea is a demonstrated antineoplastic agent, which is believed to block DNA replication by inhibiting R1 and R2 (ribonucleotide reductase) via destruction of the free radical at the enzymes active site. Induces apoptosis of in vitro myelogenous leukemia lymphocytes, and the phosphorylation of FADD and p53.
Available for research and laboratory use only.
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