Hydroxyurea USP

CAS# 127-07-1

MF# CH₄N₂O₂

MW# 76.05

Batch # 20081203

Code # Sample

Date of Mfg: 12/2008

Date of Exp: 12/2012

Synonyms: Hydrocarbamide

TEST                                        SPECIFICATION                                           RESULT

Appearance                            Crystalline Powder                                          Complies

Identification (IR)                  As per Standard                                                Complies

Melting Point                          138˚C-145˚C                                                      142˚ C

Loss on Drying                       < 0.5%                                                                 0.12%

Solubility                                 Soluble in water and Hot alcohol                  Complies

Urea                                         < 0.05%                                                               0.02%

Sulphate Ash                          < 0.2%                                                                 0.04%

Heavy Metal                          < 20ppm                                                              Complies

Assay (HPLC)                        > 97%                                                                  99.35%

Microbiological Test:

Total Plate Counts                              < 1000 cfu/g                                         Complies

Yeast and Mold                                   < 100 cfu/g                                          Complies

Enterobacteria                                     < 100 cfu/g                                          Complies

Salmonella                                            Negative                                             Complies

E.Coli                                                     Negative                                             Complies

Pseudomonas aeruginosa                  Negative                                              Complies

Hydroxyurea is a demonstrated antineoplastic agent, which is believed to block DNA replication by inhibiting R1 and R2 (ribonucleotide reductase) via destruction of the free radical at the enzymes active site. Induces apoptosis of in vitro myelogenous leukemia lymphocytes, and the phosphorylation of FADD and p53.

Available for research and laboratory use only.